A systematic review and mixed treatment comparison of monotherapy in early Parkinson's disease: implications for Latin America.
Identifieur interne : 000450 ( Main/Exploration ); précédent : 000449; suivant : 000451A systematic review and mixed treatment comparison of monotherapy in early Parkinson's disease: implications for Latin America.
Auteurs : Maribel Márquez-Cruz [Mexique] ; Juan Pablo Díaz-Martínez [Canada] ; Herman Soto-Molina [Mexique] ; Adib Jorge De Saráchaga [Mexique] ; Amin Cervantes-Arriaga [Mexique] ; Rodrigo Llorens-Arenas [Mexique] ; Mayela Rodríguez-Violante [Mexique]Source :
- Expert review of pharmacoeconomics & outcomes research [ 1744-8379 ] ; 2016.
English descriptors
- KwdEn :
- MESH :
- chemical , administration & dosage : Antiparkinson Agents.
- chemical , therapeutic use : Antiparkinson Agents.
- drug therapy : Parkinson Disease.
- physiopathology : Parkinson Disease.
- Drug Therapy, Combination, Humans, Latin America, Models, Statistical, Randomized Controlled Trials as Topic, Treatment Outcome.
Abstract
Parkinson's disease (PD) is the second most common neurodegenerative disease. There are no clinical trials comparing all available pharmacological therapies for the treatment of early PD. The objective of this review is to indirectly analyze the efficacy of antiparkinson drugs currently available in Latin America. A systematic review was performed exploring only placebo-controlled randomized trials comparing antiparkinson monotherapy (levodopa, pramipexole, rasagiline, or selegiline) in patients with PD on Hoehn and Yahr stages I through III published from January 1994 to May 2014. The primary outcome was the mean change in the Unified PD Rating Scale (UPDRS) I, II and III. A mixed treatment comparison analysis (indirect comparisons) through a random-effects model was performed. Levodopa demonstrated the highest effects in terms of UPDRS score improvement both from baseline and when compared to other treatments. Levodopa showed a 60.1% probability of granting the greatest reduction in UPDRS I, II and III.
DOI: 10.1586/14737167.2016.1135740
PubMed: 26731410
Affiliations:
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Pablo" last="Díaz-Martínez">Juan Pablo Díaz-Martínez</name><affiliation wicri:level="1"><nlm:affiliation>b McMaster University , Ontario , Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>b McMaster University , Ontario </wicri:regionArea><wicri:noRegion>Ontario </wicri:noRegion></affiliation></author><author><name sortKey="Soto Molina, Herman" sort="Soto Molina, Herman" uniqKey="Soto Molina H" first="Herman" last="Soto-Molina">Herman Soto-Molina</name><affiliation wicri:level="1"><nlm:affiliation>a Universidad Autónoma Metropolitana, Unidad Xochimilco , Mexico City , Mexico.</nlm:affiliation><country xml:lang="fr">Mexique</country><wicri:regionArea>a Universidad Autónoma Metropolitana, Unidad Xochimilco , Mexico City </wicri:regionArea><wicri:noRegion>Mexico City </wicri:noRegion></affiliation></author><author><name sortKey="De Sarachaga, Adib Jorge" sort="De Sarachaga, Adib Jorge" uniqKey="De Sarachaga A" first="Adib Jorge" last="De Saráchaga">Adib Jorge De Saráchaga</name><affiliation wicri:level="1"><nlm:affiliation>c Clinical Neurodegenerative Research Unit , National Institute of Neurology and Neurosurgery , Mexico City , Mexico.</nlm:affiliation><country xml:lang="fr">Mexique</country><wicri:regionArea>c Clinical Neurodegenerative Research Unit , National Institute of Neurology and Neurosurgery , Mexico City </wicri:regionArea><wicri:noRegion>Mexico City </wicri:noRegion></affiliation></author><author><name sortKey="Cervantes Arriaga, Amin" sort="Cervantes Arriaga, Amin" uniqKey="Cervantes Arriaga A" first="Amin" last="Cervantes-Arriaga">Amin Cervantes-Arriaga</name><affiliation wicri:level="1"><nlm:affiliation>c Clinical Neurodegenerative Research Unit , National Institute of Neurology and Neurosurgery , Mexico City , Mexico.</nlm:affiliation><country xml:lang="fr">Mexique</country><wicri:regionArea>c Clinical Neurodegenerative Research Unit , National Institute of Neurology and Neurosurgery , Mexico City </wicri:regionArea><wicri:noRegion>Mexico City </wicri:noRegion></affiliation></author><author><name sortKey="Llorens Arenas, Rodrigo" sort="Llorens Arenas, Rodrigo" uniqKey="Llorens Arenas R" first="Rodrigo" last="Llorens-Arenas">Rodrigo Llorens-Arenas</name><affiliation wicri:level="1"><nlm:affiliation>c Clinical Neurodegenerative Research Unit , National Institute of Neurology and Neurosurgery , Mexico City , Mexico.</nlm:affiliation><country xml:lang="fr">Mexique</country><wicri:regionArea>c Clinical Neurodegenerative Research Unit , National Institute of Neurology and Neurosurgery , Mexico City </wicri:regionArea><wicri:noRegion>Mexico City </wicri:noRegion></affiliation></author><author><name sortKey="Rodriguez Violante, Mayela" sort="Rodriguez Violante, Mayela" uniqKey="Rodriguez Violante M" first="Mayela" last="Rodríguez-Violante">Mayela Rodríguez-Violante</name><affiliation wicri:level="1"><nlm:affiliation>c Clinical Neurodegenerative Research Unit , National Institute of Neurology and Neurosurgery , Mexico City , Mexico.</nlm:affiliation><country xml:lang="fr">Mexique</country><wicri:regionArea>c Clinical Neurodegenerative Research Unit , National Institute of Neurology and Neurosurgery , Mexico City </wicri:regionArea><wicri:noRegion>Mexico City </wicri:noRegion></affiliation></author></analytic><series><title level="j">Expert review of pharmacoeconomics & outcomes research</title><idno type="eISSN">1744-8379</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antiparkinson Agents (administration & dosage)</term><term>Antiparkinson Agents (therapeutic use)</term><term>Drug Therapy, Combination</term><term>Humans</term><term>Latin America</term><term>Models, Statistical</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (physiopathology)</term><term>Randomized Controlled Trials as Topic</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antiparkinson Agents</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Drug Therapy, Combination</term><term>Humans</term><term>Latin America</term><term>Models, Statistical</term><term>Randomized Controlled Trials as Topic</term><term>Treatment Outcome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Parkinson's disease (PD) is the second most common neurodegenerative disease. There are no clinical trials comparing all available pharmacological therapies for the treatment of early PD. The objective of this review is to indirectly analyze the efficacy of antiparkinson drugs currently available in Latin America. A systematic review was performed exploring only placebo-controlled randomized trials comparing antiparkinson monotherapy (levodopa, pramipexole, rasagiline, or selegiline) in patients with PD on Hoehn and Yahr stages I through III published from January 1994 to May 2014. The primary outcome was the mean change in the Unified PD Rating Scale (UPDRS) I, II and III. A mixed treatment comparison analysis (indirect comparisons) through a random-effects model was performed. Levodopa demonstrated the highest effects in terms of UPDRS score improvement both from baseline and when compared to other treatments. Levodopa showed a 60.1% probability of granting the greatest reduction in UPDRS I, II and III.</div></front></TEI><affiliations><list><country><li>Canada</li><li>Mexique</li></country></list><tree><country name="Mexique"><noRegion><name sortKey="Marquez Cruz, Maribel" sort="Marquez Cruz, Maribel" uniqKey="Marquez Cruz M" first="Maribel" last="Márquez-Cruz">Maribel Márquez-Cruz</name></noRegion><name sortKey="Cervantes Arriaga, Amin" sort="Cervantes Arriaga, Amin" uniqKey="Cervantes Arriaga A" first="Amin" last="Cervantes-Arriaga">Amin Cervantes-Arriaga</name><name sortKey="De Sarachaga, Adib Jorge" sort="De Sarachaga, Adib Jorge" uniqKey="De Sarachaga A" first="Adib Jorge" last="De Saráchaga">Adib Jorge De Saráchaga</name><name sortKey="Llorens Arenas, Rodrigo" sort="Llorens Arenas, Rodrigo" uniqKey="Llorens Arenas R" first="Rodrigo" last="Llorens-Arenas">Rodrigo Llorens-Arenas</name><name sortKey="Rodriguez Violante, Mayela" sort="Rodriguez Violante, Mayela" uniqKey="Rodriguez Violante M" first="Mayela" last="Rodríguez-Violante">Mayela Rodríguez-Violante</name><name sortKey="Soto Molina, Herman" sort="Soto Molina, Herman" uniqKey="Soto Molina H" first="Herman" last="Soto-Molina">Herman Soto-Molina</name></country><country name="Canada"><noRegion><name sortKey="Diaz Martinez, Juan Pablo" sort="Diaz Martinez, Juan Pablo" uniqKey="Diaz Martinez J" first="Juan Pablo" last="Díaz-Martínez">Juan Pablo Díaz-Martínez</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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